Gas Chromatography–Mass Spectrometric Analysis of Bioactive Compounds Present in Ethanol Extract of Combretum hispidum (Laws) (Combretaceae) Root

Abstract

Knowledge of bioactive components of a given plant materia; is essential in furnishing information on possible applications. Therefore, this study was carried out to identify bioactive components in ethanol extract of Combretum hispidum roots using GCMS analysis. Results obtained from GCMS analysis of ethanol extract of Combretum hispidum roots indicated the presence of benzoic acid N'-(4,4,5,5,6,6,6-heptafluoro-3-oxo-1-phenylhex-1-enyl)-hydrazide, 1-(4-methyl-6-methoxy-2-quinolyl)-3,3'-dimethyl-(4,5'-bipyrazol)-5-ol, trans-1,2-Diphenyl-1-chloro-2-methylthio-ethene, 3-acetyl-3-demethylthiocolchicine, 1-anthracenecarboxaldehyde, 5,8,8a,9,10,10a-hexahydro-2,3-dihydroxy-10a-methyl-4-(1-methylethyl)-6-(4-methyl-, 1H-benzimidazole, 2-(2,2- dimethylpropyl)-, 1,3-benzoxathiol-2-one, 5- hydroxy-4,7-dimethyl-6-nitro-, bis(ditrifluoromethyldiphosphino)sulfide, benzeneethenylamine, 3,4-dihydroxy-N-isopropyl-, voachalotine oxindole, acetate (ester), ethanone, 1-(3-chloro-5,6-dihydro-1,4-oxathiin-2-yl)-, benzenetridecanoic acid, 3-chloro-4-methoxy-, 3-methoxy-2-(9-methyldecyl)-5-(4- methylpentyl)phenyl ester, ethyl 4,4-dimethyl-5- oxo-tetrahydrofuran-3-carboxylate, N-(4- bromophenylsulfonyl)aziridine-2,2-dicarboxylic acid diethyl ester, 1,3,5-triazin-2-amine, N,Ndihexyl-4,6-bis(2-naphthalenylthio)-, 1[5'- (hydroxymethyl)furfuryl] pyrrolidine, terephthalic acid, butyl cycloheptyl ester, 1H-pyrazole, 4,5- dihydro-1,3-diphenyl-, succinic acid, 2,2,3,3,4,4,5,5-octafluoropentyl 1-cyclopentylethyl ester. Each of the identified compounds in the extract have been documented to exhibit active pharmaceutical/medicinal activities. It was concluded that the bioactive compounds support the use of C. hispidum roots in the treatment of diseases like cancer, anaphylactic shock, renal failure, diabetes and hypertension.