Synthesis of Novel Valine-based Dipeptide Carboxamide Bearing Benzene Sulfonamide Moiety as Antimalarial Agent

Authors

Keywords:

Valine-dipeptide, carboxamide, benzensulphonamoyl butanamide, antimalarial

Abstract

Syntheses of eleven novel Valine-based dipeptide carboxamide derivatives bearing benzensulphonamide are reported. These were achieved by facile amidation reaction of p- substituted benzenesulphonamoyl alkanamides with 2-amino-4-methyl-N-substituted phenyl butanamide using classical peptide coupling reagents. The chemical structures of the synthesized compounds were established by 1H-NMR, 13C-NMR, ESI- HRMS, and FT-IR spectroscopic techniques. The synthesized compounds were evaluated for in vivo antimalarial against P. berghei. Haematological analysis was also evaluated on the synthesized compounds. At 50mg/kg body weight, the compounds 8e, 8g, 8i, 8k, 8d and 8h inhibited the multiplication of the parasite by 46-71% on day seven of post-treatment exposure comparable to the 67% reduction with artemisinin.

Author Biographies

  • James. A. Ezugwu, University of Nigeria, Nsukka, 410001, Enugu State, Nigeria

    Department of Pure and Industrial Chemistry

  • Uchechukwu C. Okoro, University of Nigeria, Nsukka, 410001, Enugu State, Nigeria

    Department of Pure and Industrial Chemistry

  • Mercy A. Ezeokonkwo, University of Nigeria, Nsukka, 410001, Enugu State, Nigeria

    Department of Pure and Industrial Chemistry

  • China Raju Bhimapaka, Division, CSIR-India Institute of Chemical Technology, Hyderabad, Telangana, India

    Organic synthesis and process chemistry

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Published

2020-05-17