Ni(II) Complex of a Novel Schiff Base Derived from Benzaldehyde and Sulphathiazole: Synthesis, Characterization and Antibacterial Studies

Abstract

New Schiff base and its Ni(II) complex, were synthesized using benzaldehyde and sulphathiazole. They were characterized using
elemental analyser, UV-visible spectrophotometer, FTIR, ¹H-NMR and ¹³C-NMR spectroscopy. IR spectral data suggested that the ligand coordinated to nickel ions through two azomethine nitrogen, and one amine nitrogen. Electronic spectral measurement indicated the occurrence of ligand to metal charge transfer. Based on the continuous variation method, metal: ligand ratio of 1:1 was proposed. Elemental analysis and spectroscopic studies suggested that the Schiff base behaved as a tridentate ligand towards nickel ion. Antibacterial sensitivity of the ligand and its Ni (II) complex were assayed in vitro against Staphylococcus
aureus, Echerichia coli, Pseudomonas aeruginosa and Salmonella typhi. It was observed that the Ni(II) complex was more potent than the Schiff base against the bacterial strains used. Therefore, the Schiff base and its Ni(II) complex may inhibit bacterial infections caused by E.coli, P.aeruginosa,S. typhi and S.aureus. The Ni(II) complex showed enhanced antibacterial activity when compared with the pure the Schiff base.