Acute Toxicity and Hypolipidemic Study of Extracts of Brillantaisia Owariensis and Andrographis Paniculata Leaf

Abstract

The study aimed to evaluate the acute toxicity and hypolipidemic effects of Brillantaisia owariensis using experimental animal models. In the acute toxicity study, no mortality or significant adverse effects were observed at doses up to 5000 mg/kg, with the LD₅₀ being greater than 5000 mg/kg, indicating the safety profile of the plant extract. In the hypolipidemic study, the administration of Brillantaisia owariensis significantly reduced total cholesterol (TC), triglycerides (TAG), low-density lipoprotein (LDL), and very low-density lipoprotein (VLDL), while increasing high-density lipoprotein (HDL). The lipid profile parameters showed that the treatment group had a mean ± standard deviation of TC (156.9 ± 10.3 mg/dL), TAG (72.4 ± 9.7 mg/dL), LDL (89.4 ± 4.5 mg/dL), VLDL (14.5 ± 1.8 mg/dL), and HDL (55.2 ± 6.0 mg/dL), compared to the control group. One-way ANOVA indicated significant differences between the treatment and control groups for all lipid parameters (p < 0.05). Post-hoc Tukey's test confirmed significant differences in TC, LDL, and HDL between groups. These findings suggest that Brillantaisia owariensis has a potential hypolipidemic effect without significant toxicity, making it a promising candidate for the management of hyperlipidemia.