Isolation and Characterization of Secondary Metabolite from the leaves Aspilia Africana (Pers.) C. D. Adams (Asteraceae)

Main Article Content

Ahamefula A. Ahuchaogu
Okenwa U. Igwe

Abstract

Aspilia africana is a medicinal plant used traditionally for treating various diseases. Phytochemical investigation of the methanol extract of the leaves has led to the isolation of squalene (hexamethyl-2, 6, 10, 14, 18, 22-tetracosahexa-ene) from the leaves of A. Africana and is known to possess significant antimicrobial activity, it has not been known to be previously isolated from Aspilia Africana. The structure of the component was elucidated based on the NMR and MS techniques and by comparison of their experimental data with literature.The purified compound was obtained by chromatographic method

Downloads

Download data is not yet available.

Article Details

Section
Articles
Author Biographies

Ahamefula A. Ahuchaogu, Abia state University, Uturu. Abia State, Nigeria

Department of Pure and Industry Chemistry

Okenwa U. Igwe, Michael Okpara university of Agriculture, Umudike, Abia State, Nigeria

Department of Chemistry

References

A.Haruna., A, Patch.,U. U., Sule, I. M., Musa, A., Sani, Y. M., Dauda, S., Lawal, M. D. & GarbaI, M. A. (2017). Isolation of Lupeol from the methanol leaf extract of Hymennocardia acida Tul. ( Euphorbiaceae) Nigerian Journal of Pharmaceutical and Biomedical Research , 2, pp. 137-142

Abii, T. A. & Onuoha, E. N. (2011). The chemical constituents of the leaf of Aspilia africana as a scientific backing to its tradomedical potentials. Agricultural Journal, 6, 1, pp. 28-30.

Akujobi, C.O., Ogbulie, J. N. & Okorondu, T. (2004). Antibacterial and nutrient potentials of Gongronema latitolium and Piper guineenses used in herbal remedies and as species. Nigerian Journal of Microbiology, 18, 1-2, pp. 241- 246.

Agyare, C., Boakye, Y. D., Bekoe, E. O., Hensel, A., Dapaah, S. O. & Appiah, T. (2016) Review: African medicinal plants with wound healing properties, Journal of Ethnopharmacology, 177, pp.85–100.

Okoli, C. O., Akah, P. A. & Okoli, A. S. (2007). Potentials of leaves of Aspilia africana (Compositae) in wound care: An experimental evaluation, BMC Complementary and Alternative Medicine, 7, 24, https://doi.org/10.1186/1472-6882-7-24. .

Okoli, C. O., Akah, P. A., Nwafor, S. V., Anisiobi, A. I.., Ibegbunam, I. N. & Erojikwe, O. (2007).Anti-inflammatory activity of hexane leaf extract of Aspilia africana C.D. Adams, Journal of Ethnopharmacology, 109, 2, pp.219–225.

Dimo, T., Tan, P. V., Dango, E., Kamtchouing, P. & Rakotonirina, S. V. (2002). Invitro vascular smooth muscle contractile activity of Aspilia africana extract on rat aortic preparations. Pharmazie, 57, 6, pp, 421-3.

Imran, H., Ahmad, M., Rahman, A., Sohail, T., Fatima, N., Igbal, W. & Yaqeen, S. S. (2015) Evaluation of wound healing effects between

Salvadora persica ointment and Solcoseryl jelly in animal model, Pakistan Journal of Pharmaceutical Sciences, 28, 5, pp. 1777-1780.

Hanna M.M & Niemetz J (1987). Studies on the anticoagulant action of Aspilia africana. Thromb Resources. 15, 47, 4, pp. 401-4077.

Khurshid, A. H. M., 2002. Chemical Constituents of Hemigraphis hirta(Acanthaceae). Pakistan Journal of Biolgical Sciences 11, pp. 1264-1266.

Rekik, M., Khedir, B. S. Moalla, K. K. & Sahnoun, Z. (2016) Healing activity of many Tunisian medicinal plants on wounds and burns, International Journal of Scientific & Engineering Research,7, 5, pp. 234-242.

Masato, K. & Wu, Y. (1994). Chemistry of 1, 2 – Dithinns synthesis of the potent antibiotic Thiarubrine A. Journal of American Chemist Society, 116, pp. 10793- 10794.

Etiosa, O. Akeem, A. & Chika, N. (2018). Phytochemical Studies and GC-MS Analysis of Chloroform Extract of the Leaves of Aspillia Africana. Asian Journal of Physical and Chemical Sciences, 4, 3, pp. 1-8.

Okokon, J. E., Nwidu, L. I. & Essiet, G. A. (2006). Evaluation of in-vivo antiplasmodial activity of Aspilia africana. International. Journal of Pharmacology. 2, 3, pp. 348-351.

Okoli ,C.O., Akah, P.A., Nwafor ,S.V., Anisiobi, A.J., Ibegbunam I. N. & Erojikwe, O. (2007). Antiinflammatory activity of hexane leaf extract of Aspilia africana. Journal of Ethnopharmacology, 109, 2, pp. 219-225

Okwu, D. E. & Josiah C (2006). Evaluation of the chemical composition of two Nigerian medicinal plants. African. Journal of Biotechnology.5, 4, pp. 357-361.

Sabale, P., Bhimani, B., Prajapati, C. & Sabalea, V. (2012) An overview of medicinal plants as wound healers, Journal of Applied Pharmaceutical Science, 2, 11, pp. 143-150.

Page, J. E., Baiza, F., Nishida, T. &Towers, G. H. M. (1992). Biologically Active Diterpenes from Aspilia mossambicensis- a Chimpanzee Medicinal Plant. Phytochemistry, 31, 10, pp. 3437-3439.

Thakur, R., Jain, N., Pathak, R. & Sandhu, S. S. (2011). Practices in WoundHealing Studies of Plants, Evidence-Based Complementary and Alternative Medicine, 2, doi:10.1155/ 2011/ -438056.

Komakech, R., Matsabisa, M. G. & Kang, Y. (2019) The Wound Healing Potential of Aspilia africana (Pers.) C. D. Adams (Asteraceae) Evidence-Based Complementary and Alternative Medicine, doi.org/10.1155/2019/7957860

Ukwueze, S. E., Aghanya, A. N., Mgbahurike, A. A. & Shorinwa, O. A. (2013) . An evaluation of the analgesic and anti-inflammatory activities of the solvent fractions of Aspilia africana (pers.). World Journal of Pharmacy and Pharmaceutical Sciences, 2, 6, pp. 94177-4189.

Oyesola, T. O., Oyesola, O. A. & Okoye, C. S. (2010) Effects of aqueous extract of Aspilia Africana on reproductive functions of femalewistar rats,” Pakistan Journal of Biological Sciences,13, 3, pp. 126–131,

Okwuonu, U., Baxter-Grillo, D. C., Njoya, H. & Iyemene, P. T. (2017). Proximate and elemental constituents of Aspilia africana (Wildsunflower) flowers. Journal of Medicinal Plants Studies, 5, 4, pp. 22–27.