Phytochemical screening and wound healing studies of Chromolaena odorata

Authors

  • Nwoke Linda Chinyere

    Michael Okpara University of Agriculture, Abia state, Nigeria
    Author
  • Uchenna Igwe Okenwa

    Michael Okpara University of Agriculture, Abia state, Nigeria
    Author
  • Onuchi Marygem Mac-Kalunta

    Michael Okpara University of Agriculture, Abia state, Nigeria
    Author
  • Johnbull O. Echeme

    Michael Okpara University of Agriculture, Abia state, Nigeria
    Author
  • Uyanwa Maryjane Nkeiruka

    Federal University of Technology, Owerri
    Author

Keywords:

Chloromolaena odorata,, phytochemical, wound healing,, column chromatography

Abstract

Chromolaena odorata (Siam weed), traditionally used for wound healing, possesses a rich profile of bioactive compounds. In this study, Chloromolaena odorata s investigated for its phytochemical and pharmacological properties. The results arising from phytochemical screening of the leaf extract validated the presence of cardiac glycosides (2.63 mg/100 g), flavonoids (4.90 mg/100 g), terpenoids (5.44 mg/100 g), alkaloids (7.56 mg/100 g), tannins (9.20 mg/100 g), and saponins (11.8 mg/100 g). Methanol crude extract of the phytochemicals obtained from the plant leaf was also used in running a column chromatography. Toxicity evaluation and dermal irritation of the methanol leaf extract of C. odorata verifies that it is non-toxic upto 5000 mg/kg. Two purified fraction of the methanol crude obtained from column chromatography and the methanol crude extract were applied for conducting wound healing tests and the test results gave a significant evidence that the extract has a wound healing property through its activity to decrease both bleeding and clothing time, which could be as a result of the increased in platlet count.. The results suggest that Chromolaena odorata plant can be exploited in as a source of traditional medicine. 

Author Biographies

  • Nwoke Linda Chinyere, Michael Okpara University of Agriculture, Abia state, Nigeria

    Department of Chemistry, Michael Okpara University of Agriculture, Umudike,. P.M.B. 7267, Umuahia, Abia State, Nigeria

  • Uchenna Igwe Okenwa, Michael Okpara University of Agriculture, Abia state, Nigeria

    Department of Chemistry, College of Physical and Applied Sciences, Michael Okpara University of Agriculture, Umudike, Abia State. 

  • Onuchi Marygem Mac-Kalunta, Michael Okpara University of Agriculture, Abia state, Nigeria

    Department of Chemistry, Michael Okpara University of Agriculture,Umudike, Umuahia, Abia state, Nigeria. P.M.B. 7267, Umuahia, Abia State.

  • Johnbull O. Echeme , Michael Okpara University of Agriculture, Abia state, Nigeria

    Department of Chemistry, College of Physical and Applied Sciences, Michael Okpara University of Agriculture, Umudike, Abia State. 

  • Uyanwa Maryjane Nkeiruka, Federal University of Technology, Owerri

    Federal University of Technology, Owerri Imo State.

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Published

2025-03-11

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