Impacts of Acute Toxicity of Heavy Metals (Hg And Pb) On Liver Enzymes of Normal Albino Wistar Rats
Keywords:
Acute Toicity, Mercury Chloride, lead nitrate, liver enzymes,, Albino Wistar rats.Abstract
his study investigates the effects of acute toxicity from heavy metals (mercury chloride and lead nitrate) on the liver enzymes of normal albino Wistar rats. Sixteen male albino rats (292-297 g) were divided into four groups, with four rats in each group. Groups 1, 2, and 3 were exposed to 40% of the lethal dose (LD50) of lead nitrate, mercury chloride, and a combination of both metals, respectively. Group 4 served as the control group. All animals had access to commercial rat mash and water during the one-week experimental period. Animals in groups 2 and 3, treated with mercury chloride and the combination of the two metals, died within a day after exposure. The results showed no significant decrease (P > 0.05) in mean serum aspartate aminotransferase (AST) and alkaline phosphatase (ALP) levels in group 1 when compared to the control. The mean serum alanine transaminase (ALT) in group 1 also showed no significant difference (P > 0.05) compared to the control. The findings indicate that the toxicity of mercury chloride and the combination of mercury chloride and lead nitrate was lethal, leading to the death of the rats. Although lead nitrate alone altered liver enzyme levels, it did not cause fatality. Therefore, human exposure to these heavy metals should be avoided to prevent deleterious effects.
Most read articles by the same author(s)
- Dorathy Edet Etim, Nnamso Effiong Essien, Aniebiet Mmekuwem Essien, Impacts of Acute Toxicity of Heavy Metals (Hg And Pb) On Liver Enzymes of Normal Albino Wistar Rats , Communication In Physical Sciences: Vol. 11 No. 4 (2024): VOLUME 11 ISSUE 4
Similar Articles
- Gideon Wyasu, Determination of Bacteriological and some physicochemical properties of Hospital wastewater , Communication In Physical Sciences: Vol. 4 No. 2 (2019): VOLUME 4 ISSUE 2
- Henrietta Ijeoma Kelle , Musa Runde, Valorization of an Agricultural Waste-Corncob: Investigation of Potassium Oxide from Corncob Ash Crystals as an Antiseptic and Disinfectant Agent , Communication In Physical Sciences: Vol. 11 No. 2 (2024): VOLUME 11 ISSUE 2
- Yakubu Azeh, Monday Musah, John Tsado Mathew, Ameh Ohiga Alfa Ebune, Fatima Ibrahim, Umar Musa Tanko, Muhammad Umar Badeggi, Aliyu Ahmed Ibrahim, Abdulkarim Mohammed Awwal, Aishetu Ibrahim Muhammad, Karima Tani Muhammad, Ismail Haruna, Nasiru Ibrahim, Preparation of Conductive Antibacterial Film of Organoclay Origin , Communication In Physical Sciences: Vol. 12 No. 1 (2024): VOLUME 12 ISSUE 1
- Ikimi, Charles German, Umeoguaju, Francis Uchenna, Ononamadu, Chimaobi James, Exploration of Vitreous Biochemical Markers for Postmortem Discrimination of Carbon Monoxide Toxicity: Insights from Animal Model , Communication In Physical Sciences: Vol. 11 No. 4 (2024): VOLUME 11 ISSUE 4
- Ikimi, Charles German, Umeoguaju, Francis Uchenna, Ononamadu, Chimaobi James, Exploration of Vitreous Biochemical Markers for Postmortem Discrimination of Carbon Monoxide Toxicity: Insights from Animal Model , Communication In Physical Sciences: Vol. 11 No. 4 (2024): VOLUME 11 ISSUE 4
- Emeka C. Ogoko, Water Quality Assessment of Dug Wells in Lagos Island, Southwestern Nigeria , Communication In Physical Sciences: Vol. 4 No. 2 (2019): VOLUME 4 ISSUE 2
- Azeh Yakubu, Mohammed Aliyu-Paiko, Asseh Emmanuel, The Potential of Arginine-Modified Nanoclay Suspension Against Fungi and Bacteria Infestation in Maize and Groundnut , Communication In Physical Sciences: Vol. 12 No. 2 (2025): VOLUME 12 ISSUE 2
- Usoro Monday Etesin, Abigail Louis Essien, Distribution of Heavy metals in sediments and surface waters from Iko River Marine Ecosystems, Akwa Ibom State, Niger Delta, Nigeria , Communication In Physical Sciences: Vol. 12 No. 2 (2025): VOLUME 12 ISSUE 2
- Humphrey Ibifubara, Hassan Saheed Ayobami, Erusiafe Nald Ese, Design And Implementation of Cost Effective SMS-Based Online Voting System for Credible election in Nigeria , Communication In Physical Sciences: Vol. 12 No. 2 (2025): VOLUME 12 ISSUE 2
- Charles German Ikimi, Ijeoma Cynthia Anyaoku, Maryann Nonye Nwafor, Biomarker Potentials of Postmortem Vitreous Biochemical Parameters For Resolving Disputed Causes of Death by Drowning Using Animal Models , Communication In Physical Sciences: Vol. 12 No. 2 (2025): VOLUME 12 ISSUE 2
You may also start an advanced similarity search for this article.