Synthesis, Spectroscopic Characterization and Biological Studies Of 2-{[(2-hydroxy-5-nitrophenyl)methylidene]amino} nicotinic acid and Iron (II) complexes

Abstract

Authors: I. G. Osigbemhe, M. E. Khan, A. Mutairu and I. F. Esekhaigb

Iron (II) complexes of 2-{[(2-hydroxy-5nitrophenyl) methylidene]amino} nicotinic acid obtained from o-phenylenediamine and 5nitrosalicaldehyde were prepared and characterized using AAS, UV-Visible, IR, 1HNMR, 13CNMR, and GCMS. The synthesized complex was screened against some microbes in order to establish their potentials antimicrobial activity with reference to some known drugs. The results obtained indicated that, the Schiff base exhibited antimicrobial action against all the tested microbes (except Candidas. albicans isolate, which exhibited zero diameter zone of inhibition) including Escherichia coli, Bacillus subtilis, Staphylococcus aureus, Klebsiella pneumonia, Enterobacter aeruginosa, and Proteus mirabilis.. It was also found that the synthesized Schiff base exhibited two digits purity range, implying that it was relatively stable. The biological activity of the metal complex of the Schiff base was found to be better than that of synthesized Schiff base.