Identification of Potential Aedes aegypti Juvenile Hormone Inhibitors from Methanol Extract of Leaves of Solanum erianthum: An In Silico Approach
Keywords:
Health challenge, Aedes aegypti, insecticide, Solanum erianthum, DockingAbstract
This study explores the potential of phytoconstituents from the methanol extract of Solanum erianthum leaves as inhibitors of juvenile hormones in Aedes aegypti using an in silico approach. Gas Chromatography-Mass Spectrometry (GC-MS) analysis identified key compounds in the extract, including γ-sitosterol (40.25%), Ergost-5-en-3-ol (8.75%), and Stigmasterol (8.17%). Molecular docking simulations with the juvenile hormone-binding protein (PDB ID: 5V13) revealed that Ergost-5-en-3-ol (−8.316 kcal/mol) and 9,19-cycloergost-24(28)-en-3-ol (−8.388 kcal/mol) exhibited superior binding affinities compared to the standard juvenile hormone inhibitor Pyriproxyfen (−6.081 kcal/mol). Additionally, Phenol, 2,4-bis(1,1-dimethylethyl) (−7.063 kcal/mol) and DL-α-Tocopherol (−6.411 kcal/mol) showed moderate binding affinities. The physicochemical properties of these compounds, including their potential for intestinal absorption and blood-brain barrier penetration, were favourable. These findings suggest that the identified compounds may serve as promising bioinsecticides for controlling Aedes aegypti and mitigating the spread of vector-borne diseases.
Most read articles by the same author(s)
- Taye Temitope Alawode, Identification of Potential Aedes aegypti Juvenile Hormone Inhibitors from Methanol Extract of Leaves of Solanum erianthum: An In Silico Approach , Communication In Physical Sciences: Vol. 11 No. 4 (2024): VOLUME 11 ISSUE 4
- Taye Temitope Alawode, Molecular Docking Studies on Eudesmane Sesquiterpenes as Potential Anti-leishmanial Agents , Communication In Physical Sciences: Vol. 12 No. 1 (2024): VOLUME 12 ISSUE 1
- Taye Temitope Alawode, Molecular Docking Studies on Eudesmane Sesquiterpenes as Potential Anti-leishmanial Agents , Communication In Physical Sciences: Vol. 11 No. 4 (2024): VOLUME 11 ISSUE 4
Similar Articles
- Taye Temitope Alawode, Identification of Potential Aedes aegypti Juvenile Hormone Inhibitors from Methanol Extract of Leaves of Solanum erianthum: An In Silico Approach , Communication In Physical Sciences: Vol. 11 No. 4 (2024): VOLUME 11 ISSUE 4
- Taye Temitope Alawode, Molecular Docking Studies on Eudesmane Sesquiterpenes as Potential Anti-leishmanial Agents , Communication In Physical Sciences: Vol. 11 No. 4 (2024): VOLUME 11 ISSUE 4
- Taye Temitope Alawode, Molecular Docking Studies on Eudesmane Sesquiterpenes as Potential Anti-leishmanial Agents , Communication In Physical Sciences: Vol. 12 No. 1 (2024): VOLUME 12 ISSUE 1
- Bertha Onyenachi Akagbue, Mark Ndako Ibrahim, Oseigbovo Favour Ofure, Oluwaiye Unity Ekugbe, Onah Kyrian, Chibuzor Titus Amaobichukwu, Mu’awiya Baba Aminu, Pam Dajack Dung, Suleiman Isa Babale, Sadiq Mohammed Salisu, Comprehensive Assessment and Remediation Strategies for Air Pollution: Current Trends and Future Prospects; A Case Study in Bompai Industrial Area, Kano State, Nigeria. , Communication In Physical Sciences: Vol. 10 No. 1 (2023): VOLUME 10 ISSUE 1
- Chidumebi Uzoho, The Public Health Impact of Airborne Particulate Matter: Risks, Mechanisms, and Mitigation Strategies , Communication In Physical Sciences: Vol. 12 No. 2 (2025): VOLUME 12 ISSUE 2
- Bertha Onyenachi Akagbue Akagbue, Mu’awiya Baba Aminu , Effect of Na-22, Cl-36, 3-H, and P-32 Exposure on Laboratory Clinical Researchers , Communication In Physical Sciences: Vol. 9 No. 4 (2023): VOLUME 9 ISSUE 4
- Faith Osaretin Osabuohien, Review of the Environmental Impact of Polymer Degradation , Communication In Physical Sciences: Vol. 2 No. 1 (2017): VOLUME 2 ISSUE 1
- Emeka Chima Ogoko, Aletan, Uduak Irene, Osu Charles Ikenna, Henrietta Ijeoma Kelle, Nnamdi Ibezim Ogoko, Heavy Metal Status and Health Risks Assessment of Some Local Alcoholic and Non-Alcoholic Beverages Consumed in Aba, Nigeria , Communication In Physical Sciences: Vol. 11 No. 4 (2024): VOLUME 11 ISSUE 4
- Olusegun Sawole, Kolawole Abiodun Egunjobi, Adebola Daniel Awofodu, Health Risk Assessment of Natural Radionuclides Ingestion from Selected Edible Crops in Farmlands Around Limestone Excavation Area in Ewekoro, Ogun State , Communication In Physical Sciences: Vol. 9 No. 4 (2023): VOLUME 9 ISSUE 4
- Chidumebi Uzoho, The Role of Contaminated Water in Food Poisoning: An Assessment of Agricultural and Processing Practices , Communication In Physical Sciences: Vol. 12 No. 3 (2025): VOLUME 12 ISSUE 3
You may also start an advanced similarity search for this article.