Ni(II) complex of (3,3-dimethyl-7-oxo-6-(2-Phenylacetamido)-4-thia1-Azabicyclo[3.2.0]heptane-2-carboxylic acid : Synthesis, characterization and antibacterial activities
Keywords:Ligand, chelation, spectra, bacteria, inhibition, complexes
Communication in Physical Sciences 2020, 5(1): 14-23
Authors: Ifeanyi E. Otuokere, U. F. Robert & K. K. Igwe
Received 04 March 2020/Accepted 27 March 2020
The ligand (3,3-Dimethyl-7-oxo- 6-(2-phenylacetamido)-4-thia-1-azabicyclo[3.2.0-] heptane-2-carboxylic acid (DPTA) is a β-lactamin derivative used in the treatment of infections caused by gram-positive bacterial strains and few gramnegative bacterial strains.[Ni(DPTA)] was synthesized by the reaction of DPTA with NiCl2.6H2O. Physical properties such as solubility, colour and melting point were determined for the ligand, DPTA and the synthesized complex, [Ni(DPTA)]. The complex is found to be light green in colour. The ligand and the complex are ionic in nature with molar conductivity values of 218.2 and 126.0 Sm2mol-1 respectively. The complex was characterized based on elemental analysis, UVVisible, infrared, 1H NMR and 13C NMR spectroscopy. Spectroscopic data suggested that the DPTA coordinated to Ni ion through OH, C=O of amide, C=O of carboxylic acid, C=O of β-lactam and NH functional groups. Also since DPTA was coordinated to nickel centre through five sites it was also proposed that it acted as a pentadentate ligand around the nickel centre. The antibacterial studies of the ligand and its nickel complex were carried out against four-gram negative bacterial strains (Escherichia coli, Enterobacter cloacae, Pneumonia aeruginosa and Campylobacter fetus) and four-gram positive bacterial strains (Staphylococcus aureus, Bacillus substilis, Bacillus cerus and Enterococcus faecalis). The results showed that [Ni(DPTA)] exhibited better antibacterial activity than DPTA. Its study concluded that the process of chelation affected the biological behavior of the compound which in turn increase the inhibitory potential against the bacterial strains.
Anacona, J. R. and Figueroa, E. M. (1999). Synthesis and characterization of metal complexes with penicillin. Journal of Coordination Chemistry. 48(2): 181-189.
Angelo, F., (2020). Metal complexes, an untapped source of antibiotic potential, Perspective, 9(2): 90 Angelo, F., Johannes, Z., Alysha, G.E., Murray, B., Stefan, B. and Christopher (2020). Metal complexes as a promising source for new antibiotics, Chemical Science, advance article.
Geary, W. J. (1971). The use of conductivity measurements in organic solvents for the characterization of coordination compounds. Coordination Chemistry Reviews. 7(1): 81-122. Islam, F., Hossain, M. A., Shah, N. S., Barba, H. T., Kabir, M. A., Khan, M. J. and Mullick, R. (2015). Synthesis, characterization, and antimicrobial activity studies of Ni (II) complex with Pyridine as a ligand. Journal of Chemistry.2015:1-8
Islam, M. R., Islam, S. M., Noman, Abu-S. M., Khanam, J. A., Monsin-Ali, S. M., Alam, S. and Lee-Wong, M. (2007). “Biological screening of a novel nickel (II) tyrosine complex. Mycobiology. 35(1): 25-29.
Mohamed, G. G., Omar, M. M. and Hindy, A. M. (2006). Metal complexes of Schiff bases: preparation, characterization and biological activity. Turkish Journal of Chemistry. 30(3): 361-382.
Najlaa, S.A., Ehab, M.Z., Gehad, G.M and Hayam, A.A. (2020). Synthesis, spectroscopic characterization, molecular docking and evaluation of antibacterial potential of transition metal complexes obtained using triazole chelating ligand. Journal of Chemistry, 1 -12.
Pahontu, E., Ilieș, D.C., Shova, S., Oprean, C., Păunescu, V., Olaru, O. T., Rădulescu, F. Ș., Gulea, A., Roșu, T. and Drăgănescu, D. (2017). Synthesis, Characterization, Antimicrobial and Antiproliferative Activity Evaluation of Cu (II), Co (II), Zn (II), Ni (II) and Pt (II) complexes with Isoniazid-derived compound. Molecules. 22(4): 650.
Pahontu, E., Fata, V., Gulea, A., Poirier, D., Tapcov, V. and Rosu, T. (2013). Synthesis, Characterization of some new Cu (II), Ni (II) and complexes with Salicylidene Thiosemicarbazones: Antibacterial, antifungal and in vitro antileukemia activity. Molecules. 18(8): 8812-8836.
Rafique, S., Idrees, M., Nasira, A., Akbar, H. and Atha, A. (2010). Transition Metal Complexes as Potential Therapeutic Agents. Biotechnological and Molecular Biological review. 5(2): 38-45.
Thompson, K. H. and Orgiv, C. (2004). Metals ions in biological system. CRC Press 41: 221-230.
Thompson, K. H.and Orvig, C. (2006). Vanadium in diabetes: 100 years from phase 0 to phase I. Journal of Inorganic Biochemistry. 100(12):1925–1935.
Copyright (c) 2010 The Journal and the author
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.