Effect of Ethanolic Extract of Bryophyllum pinnatum Leaves On Haematological Parameters of Albino Wistar Rats Exposed to Cadmium Chloride

Abstract

Dorathy Edet Etim, John Cookey Ekpo, Aniebiet Mmekuwem Essien and  Imaobong Nyambi Akpet

This study was undertaken to investigate the effect of ethanolic extract of Bryophllum pinnatum leaves on haematological parameters of male albino Wistar rats exposed to cadmium chloride. seventeen  (17) male albino Wistar rats were divided into five (5) groups consisting of five (5) rats  each: Those in groups 1 and 2 were labelled as normal and negative control respectively. Experimental animals from groups 2 to 5 were treated with groups1ml of 26mg/kgbwt of cadmium chloride for seventeen  (17) days. Those animals in test groups (3, 4 and 5) were also treated with 1ml of 100 mg/kgbwt, 200mg/kg/bwt and 300mg/kgbwt ethanolic extract of Bryophyllumpinnatum respectively for r twenty-one (21) days. After the exposure to CdCl₂ solution for 17 days.  The result obtained showed that there was  no significant  increase (P>0.05) in red blood cell (RBC), and PCV, non-significant  while a slight decrease (P>0.05) in HGB and MCHC parameters were observed for the animals in group 1 (the normal control group) compared to those in the negative control group (group 2). There was a significant increase in PLT in the negative control group compared to the normal and test group members. Therefore the plant extract has the potency of treating menorrhagia, haemorrhoids and hematemesis and can be employed after satisfactory pre and post-clinical screenings.