Synthesis, Spectroscopic Characterization and Biological Studies Of 2-{[(2-hydroxy-5-nitrophenyl)methylidene]amino} nicotinic acid and Iron (II) complexes


  • M. E. Khan Federal University Lokoja, Kogi State, Nigeria


Synthesis, characterization, Schiff base, iron complex, antimicrobial activity


Communication in Physical Sciences 2020, 5(2) 106-116

Authors: I. G. Osigbemhe, M. E. Khan, A. Mutairu and I. F. Esekhaigb

Received 02 March 2020/Accepted 20 April 2020

Iron (II) complexes of 2-{[(2-hydroxy-5nitrophenyl) methylidene]amino} nicotinic acid obtained from o-phenylenediamine and 5nitrosalicaldehyde were prepared and characterized using AAS, UV-Visible, IR, 1HNMR, 13CNMR, and GCMS. The synthesized complex was screened against some microbes in order to establish their potentials antimicrobial activity with reference to some known drugs. The results obtained indicated that, the Schiff base exhibited antimicrobial action against all the tested microbes (except Candidas. albicans isolate, which exhibited zero diameter zone of inhibition) including Escherichia coli, Bacillus subtilis, Staphylococcus aureus, Klebsiella pneumonia, Enterobacter aeruginosa, and Proteus mirabilis.. It was also found that the synthesized Schiff base exhibited two digits purity range, implying that it was relatively stable. The biological activity of the metal complex of the Schiff base was found to be better than that of synthesized Schiff base.


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Author Biography

M. E. Khan , Federal University Lokoja, Kogi State, Nigeria

Department of Chemistry


Afanas, B., Dorozkhko, A. L., Brodskii, A. V., Kostyuk, V. A. & Potapovitch, A. I. (1989). Chelating and free radical scavenging mechanism of inhibitory action of rutin and quercetin in lipid peroxidation. Biochemical pharmacology, 38, pp.178-1739.

Boron, J. E. & Fingold, S. M. (1990). Method for testing Antimicrobial effectiveness. In: Bailey Scotts Diagnostic Microbiology, 8th edition. Mosby, CV Missouri, 6, 8, pp. 23-28.

Chohan, Z. H., Rau, A., Noreen, S., Scozzafava, A & Supuran, C. T. (2002). Antibacterial cobalt (II), nickel (II) and zinc (II) complexes of nicotinic acid n derived Schiff-bases. Journal of Enzyme Inhibition and Medicinal Chemistry, 17, 2, pp. 101-106.

Emma, A. A, E., Khaled, H. H., Safaa, K. H. & Nabil, S.Y. (2008): Synthesis, characterization and biological activity of some transition metal complexes with Schiff bases derived from 2formylindole, salicylaldehyde, N[amino rhod- amine. Australian Journal of Basic and Applied Sciences, 2. 2. Pp. 210-220.

Fasina, T. M. & Ogundele (2014); Synthesis, Characterization and antimicrobial activity of some transition metal complexes of Schiff bases from O-phenylenediamine and 5-nitrosaldehy- de. Der pharm chemical, 6, 4, pp. 8 – 22.

Gajendra, K., Dharmendra, K., Singh, C. P., Amit, K. & Rana, V. B. (2010). Synthesis, physical characterization and biological evaluation of Schiff base Cr (III), Mn (III), Fe (III) complexes. European journal of Chemistry, 7, 3, pp. 813820.

Gupta, K. C., & Sutar, A. K. (2008). Catalytic activities of Schiff base transition metal complexes. Coordinator Reviews, 12, 253, pp.1420-1450.

Loudon, G. M. (2002). Organic Chemistry. Addison-Wesley, California, Ed. 4 5(8): 74.

More, G., Raut, D., Aruna, K. & Bootwala, S. (2017). Synthesis, Spectroscopic characteriza- tion and antimicrobial activity evaluation of new tridentate Schiff bases and their Co(II) complexes. Journal of Saudi Chemical Society, 21, 8, pp. 954-964.

Nsglah, A. M., Awad, H. M., Bhat, M. A., Al-Omar, M. A. & Amir, A. E. (2015). Microwave assisted synthesis and antimicrobial activity of some novel isatin Schiff bases linked to nicotinic acid via certain amino acid bridge. Journal of Chemistry, 1155/2015/364841.

Tolulope, F., Dueke-Eze, M., Cordella, U. & Nneoma, I. F. (2017). Synthesis, spectroscopic and antimicrobial properties of Co(II), Ni(II) and Cu(II) complexes of )E)-N-(2-hydroxy-5nitrobenzylidene) isonicotinohydrazide. Journal of Applied Environmental Management, 21, 1, pp. 120-125.