Ni(II) Complex of a Novel Schiff Base Derived from Benzaldehyde and Sulphathiazole: Synthesis, Characterization and Antibacterial Studies

Main Article Content

Ifeanyi E. Otuokere
J. C. Anyanwu
K. K. Igwe

Abstract

Communication in Physical Sciences 2020, 5(2): 145-155


Authors: Ifeanyi. E. Otuokere, J.C. Anyanwu and K.K. Igwe
Received 09April 2020/Accepted 01May 2020


New Schiff base and its Ni(II) complex, were synthesized using benzaldehyde and sulphathiazole. They were characterized using
elemental analyser, UV-visible spectrophotometer, FTIR, 1H-NMR and 13C-NMR spectroscopy. IR spectral data suggested that the ligand coordinated to nickel ions through two azomethine nitrogen, and one amine nitrogen. Electronic spectral measurement indicated the occurrence of ligand to metal charge transfer. Based on the continuous variation method, metal: ligand ratio of 1:1 was proposed. Elemental analysis and spectroscopic studies suggested that the Schiff base behaved as a tridentate ligand towards nickel ion. Antibacterial sensitivity of the ligand and its Ni (II) complex were assayed in vitro against Staphylococcus
aureus, Echerichia coli, Pseudomonas aeruginosa and Salmonella typhi. It was observed that the Ni(II) complex was more potent than the Schiff base against the bacterial strains used. Therefore, the Schiff base and its Ni(II) complex may inhibit bacterial infections caused by E.coli, P.aeruginosa,S. typhi and S.aureus. The Ni(II) complex showed enhanced antibacterial activity when compared with the pure the Schiff base. 

Downloads

Download data is not yet available.

Article Details

Section
Articles
Author Biographies

Ifeanyi E. Otuokere, Michael Okpara University of Agriculture, Umudike, Nigeria

Department of Chemistry

J. C. Anyanwu, Michael Okpara University of Agriculture, Umudike, Nigeria

Department of Chemistry

K. K. Igwe , Michael Okpara University of Agriculture, Umudike, Nigeria

Department of Veterinary Biochemistry and
Animal Production

References

Abd El-halim, H. F., Omar, M. M. & Mohamed, G.

G. (2011). Synthesis, structural, thermal

studies and biological activity of a tridentate

Schiff base ligand and their transition metal

complexes. SpectrochimicaActa A: Molecular

and Biomolecular Spectroscopy. 78, pp. 36–44.

Abdulghani, A. J. & Hussain, R. K. (2015).

Synthesis and Characterization of Schiff Base

Metal Complexes Derived from Cefotaxime

with 1H-indole-2,3-dione (Isatin) and 4-N,Ndimethyl-aminobenzaldehyde,. Open Journal of

Inorganic Chemistry, 5, pp. 83-101.

Amir, M., Hasan, S. M. & Wadood, A. L. (2002).

Synthesis and antibacterial activity of 1-Isonicotinyl-3-methyl-4(substituted phenyl hydrazono)-2-pyrazolin-5-ones. Oriental Journal of

Chemistry. 18, pp. 351-353.

Anacona, J. R. & Lopez, M. (2012). Mixed ligand

nickel (II) complexes containing sulfathiazole

and cephalosporin antibiotics: synthesis,

characterization and antibacterial activity.

International Journal of Inorganic Chemistry,

, https://doi.org/10.1155/2012/106187

Anacona, J. R., Rodriguez, J. L & Camus, J.

(2018). Synthesis, characterization and

antibacterial activity of a Schiff base derived

from cephalexin and sulphathiazole and its

transition metal complexes. Spectrochimoca

Acta A: Molecular and Bimolecular

Spectroscopies, 14, pp. 129-102.

Anacona, J. & Santaella, J. (2013). Synthesis,

magnetic and spectroscopic studies of a Schiff

base derived from cephaclor and 1, 2-

diaminobenzene and its transition metal

complexes. SpectrochimicaActa Part A:

Molecular and Biomolecular Spectroscopy. 115,

pp. 800-804.

Angelo, F., (2020). Metal complexes, an untapped

source of antibiotic potential. Perspective, 9(2),

pp. 90

Angelo, F., Johannes, Z., Alysha, G.E., Murray, B.,

Stefan, B. & Christopher (2020). Metal

complexes as a promising source for new

antibiotics, Chemical Science, In Press

Ben Saber, S. M., Mailub, A. A., Hudere, S. S. &

El-ajaily, M. M. (2005). Complexation behavior

of some Schiff base complexes toward

transition metal ions. Micro Chemical Journal,

, pp. 191- 194.

Canpolat, E. (2014). Synthesis and characterization

of dioxouranium (VI) complexes of Schiff

bases (mixed-ligands Part 1), BEU Journal of

Science, 3, 1, pp. 74-80

Chohan, Z. H. Pervez, H., Khan, K. M. & Supuran,

C.T. (2005). Organometallic-based antibacterial

and antifungal compounds: transition metal

complexes of 1,1ᶦ

-diacetylferrocene-derived

thiocarbohydrazone,carbohydrazone, thiosemicarbazone and semicarbazone.Journal of

Communication in Physical Sciences 2020, 5(2):145-155 154

Enzyme Inhibitory Medical Chemistry. 20, 1,

pp. 81-89.

Chohan, Z. H., Youssoufi, M. H., Jarrahpour, A.&

Hadda, T. B. (2010). Identification of

antibacterial and antifungal pharmacophore sites

for potent bacteria and fungi inhibition.

European Journal of Medicinal Chemistry. 45,

pp. 1189-1199.

Da Silva, C. M., Da Silva, D. L., Modolo, L. V.,

Alves, R. B., De Resende, M. A., Martins, C. V.

B. & De Fatima, A. (2011). Schiff bases: A short

review of their antimicrobial activities. Journal

of Advanced Research. 2, pp. 1-8.

Deng, B. T. (2016). Study on Schiff bases derived

from sulfathiazole and sulfamethoxypyridazine.

Journal of Chemical Society of Pakistan, 38, 1,

pp. 133 – 138.

Ergene, E., Sivas, H. &Benkli, K. (2010).

Biological activities of Cu(II) and Hg(II)

complexes of a heptadentate Schiff base ligand.

Turkish Journal of Biology. 34, 4, pp. 379-387.

Geary, W. J. (1971). The use of conductivity

measurements in organic solvents for the

characterization of coordination compounds.

Coordination Chemistry Reviews. 7, 1, pp. 81-

Igbal, A. & Hoque, F. (2016). Synthesis,

Characterization and Antimicrobial Studies of

Schiff Base Ligand-Derived from Amoxicillin

and Benzaldehyde. Bangladesh Pharmaceutical

Journal, 19, 2, pp. 211-214.

Keskioˇglu, E., G¨und¨uzalp, A.B., Ete, S. C.,

Hamurcu, F. & Erk, B. (2008).

SpectrochimicaActa Part A: Molecular and

Biomoslecular Spectroscopy. 70, pp. 634.

Kshash, A.H. (2010) Synthesis of Some Schiff

Bases by Direct Condensation for Cefotaxime

(Claforan) and Benzaldehyde or Its

Substitutions and Study of Their Antibacterial

Activity. Journal of Anbar Veterinary Science,

, pp. 125-132.

Lekha, L., Raja, K. K., Rajagopal, G. &

Easwaramoorthy, D. (2014). Synthesis,

spectroscopic characterization and antibacterial

studies of lanthanide (III) Schiff base complexes

containing N, O donor atoms. Journal of

Molecular Structure. 1056, pp. 307-313.

More, S. V., Dongerkhadekar, D. V., Chavan, R.

N., Jadhav, W. N., Bhusare, S. R.& Pawar, R. P.

(2002). Synthesis and antibacterial activity of

new Schiff bases, 4thiazolidinones and 2-

azetidinones. Journal of Indian Chemical

Society. 79, pp. 768-769.

Nadiah, A. & Uwaisulqarni, O. (2013). Synthesis

and characterization of Co(II), Cu(II), Cd(II),

Zn(II) and Ni(II) complexes of Schiff base

ligands derived from S-benzyldithiocarbazate

and acetophenone with their biological activity

studies, Journal of Engineering, 3, 8, pp. 38 –

Najlaa, S.A., Ehab, M., Zayeb, G.G.M & Hayam,

A.A (2020). Synthesis, spectroscopic

characterization, molecular docking and

evaluation of antibacterial potential of

transition metal complexes obtained using

triazole chelating ligand, Journal of Chemistry,

, pp 1-12.

Narendra, K.C and Parashuram, M. (2014). In vitro

antimicrobial screening of metal complexes

of Schiff base derived from streptomycin and

amoxicillin: Synthesis, characterization and

molecular modeling, American Journal of

Applied Chemistry, 2, 1, pp. 19-26

Osigbemhe, I. D., Khan, M. E & Esekhaigbe, I. F.

(2020). Synthesis, Spectroscopic

Characterization and Biological Studies Of 2-

{[(2-hydroxy-5-

nitrophenyl)methylidene]amino} nicotinic acid

and Iron (II) complexes. Communication in

Physical Sciences, 5, 2, 106-116.

Otuokere, I. E.& Chinweuba, A. J. (2011).

Synthesis, characterization and fungicidal

activity of 3-chloro-4-methyl-N-[(1E)-1-

phenylethylidene]aniline ligand and its metal

complexes.Journal of Chemical and Pharmaceutical Research, 3, 6, pp. 905-911

Otuokere, I. E., Robert, U. F & Igwe, K. K. (2020).

Ni(II) complex of (3,3-dimethyl-7-oxo-6-(2-

Phenylacetamido)-4-thia1-

Azabicyclo[3.2.0]heptane-2-carboxylic acid :

Synthesis, characterization and antibacterial

activities.

Rajendran, S. P.& Karvembu, R. (2002). Synthesis

and antifungal activities of Schiff bases derived

from 3amino-2H-pyrano [2,3]-quinolin-2 ones.

Indian Journal of Chemistry. 41B, pp. 222-224.

Rakesh, C.R., Md, K., Haque, M.M. & Md, A.A

(2015). Synthesis, characterization and

antimicrobial activity of Co(II), Cu(II) and

Mn(II) metal complexes of Schiff base ligand

derived from cinnamaldehyde and

ethylenediamine, International Journal of

Chemical Studies, 3, 2, pp. 17 - 19.

Rehder, D., Santoni, G., Licini, G. M., Schulzke,

C.& Meier, B. (2003). The medicinal and

catalytic potential of model complexes of

vanadate? dependent haloperoxidases.

Coordination Chemistry Reviews. 237, pp. 53-

Rehder, D. (2003). Biological and medicinal

aspects of vanadium. Inorganic Chemistry

Community. 6, pp.604-617.

Shebl, M. (2008). Synthesis and spectroscopic

studies of binuclear metal complexes of a

tetradentate N2O2 Schiff base ligand derived

from 4,6-diacetylresorinol and benzylamine.

SpectrochimicaActa: A Molecular Biomolecular

Spectroscopy. 70, 4, pp. 850-859.

Sinthuja, S.A. & Kumari, S.S. (2013) Synthesis,

Spectroscopic Investigation and Antimicrobial

Studies on Some Schiff Base Complexes of

Cu(II) and Ni(II). Journal of Chemical and

Pharmaceutical Research, 5, pp. 303-309.

Tirmizi, S. A., Wattoo, F.H., Wattoo, M. H. S,

Sarwar, S. Memon, A. N. (2012).

Spectrophotometric study of stability constant

of cimetidine-Ni(II) complex at different

temperatures, Arabian Journal of Chemistry, 5,

pp. 309 – 314

Umendra, K & Sulekh, C. (2011). Synthesis,

spectroscopic characterization of some Schiff

base complexes derived from 2-

methylcyclohexanone and their activity against

some fungi, Journal of Saudi Chemical Society,

, pp. 19 – 24.

Wu, J. Z. & Yuan,L. (2004). Synthesis and DNA

interaction studies of a binuclear Ruthenium (II)

complex with 2, 9-bis (2-imidazo [4, 5-

f][1,10]phenenthroline)-1, 10-phenanthroline as

bridging and intercalating ligand. Journal of

Inorganic Biochemistry. 98, 1, pp. 41-45.

Xishi, T., Xian, H. Y., Qiang, C. & Minyu, T.

(2003). Synthesis of Some Transition Metal

Complexes of a Novel Schiff Base Ligand

Derived from 2, 2’ – Bis(pMethoxyPhenylamine) and Salicylic Aldehyde.

Molecule. 8, pp. 439-443.

Zahid, H.C., Hazoor, A. S. & Claudiu, T.S. (2012).

Synthesis, characterization and biological

studies of some sulfonamide Schiff bases and

some of their metal complexes, Journal of

Enzyme inhibition and Medicinal Chemistry, 27,

, pp. 58 - 68

Zhang, N., Fan, Y., Zhang, Z., Zuo, J., Zhang, P.,

Wang, Q. & Liu, S. Bi, C. (2012). Synthesis,

crystal structures and anticancer activities of

three novel transition metal complexes with

Schiff base derived from 2-acetylpyridine and Ltryptophan. Inorganic Chemistry Communi -

cations. 22,pp. 68-72